Diagnostic Menu

Cumulative Longevity Programmes & Screening

Every longevity investigation at Hisential is doctor-led, cumulative, and designed to establish an objective baseline of biological ageing, microbial health, and physical performance.

Core Longevity Tiers

The Four Cumulative Longevity Tiers

Start at the level that aligns with your health objectives and step up seamlessly over time.

Tier 01

The Janus — The Baseline

Epigenetic Biological Age & Gut Microbiome Foundation

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The Janus is designed for patients seeking their first empirical measurement of biological decay versus chronological age. Rather than relying on static DNA tests that cannot change, The Janus evaluates dynamic DNA methylation marks alongside comprehensive gut microbiome genomic sequencing.

Diagnostic Inclusions:

Pre-test Medical Goal-Setting Consultation
Epigenetic Biological Age Testing (DNA methylation array)
Gut Microbiome Analysis (High-throughput sequencing)
Physician-Led Longitudinal Action Plan
Dedicated Personal Health Concierge coordination

Candidate Profile & Protocol:

Best For: Busy professionals establishing a mid-life health baseline or seeking objective feedback on existing wellness protocols.
Sample: Venous blood or saliva at Mandarin Gallery + at-home stool kit.
Turnaround: 14 to 21 business days.

Tier 02

The Apollo — The Functional

Everything in The Janus + Segmental Body Composition & Grip Strength

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Muscle mass is the primary metabolic sink for glucose disposal and the most reliable clinical hedge against age-related frailty. The Apollo incorporates hospital-grade segmental InBody multi-frequency bioimpedance analysis and calibrated dynamometry to measure muscle quality and frailty risk.

Diagnostic Inclusions:

All Inclusions from The Janus Baseline
InBody Segmental Body Composition Analysis (Visceral fat area, skeletal muscle mass, intracellular water ratio)
Calibrated Grip Strength Dynamometer Evaluation (Upper-limb neuromuscular strength and frailty index)
Targeted Hypertrophy & Resistance Training Prescription

Candidate Profile & Protocol:

Best For: Individuals tracking muscle-to-fat ratios, metabolic syndrome risk, and sarcopenia prevention.
Turnaround: InBody & Grip test reviewed immediately during consultation; genomics in 14–21 days.

Tier 03

The Helios — The Performance

Everything in The Apollo + VO2 Max Cardiopulmonary Gas Analysis

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Cardiorespiratory fitness (VO2 Max) exhibits the single strongest inverse association with all-cause cardiovascular mortality in epidemiological medicine. Rather than estimating VO2 Max from heart rate algorithms, The Helios performs laboratory breath-by-breath cardiopulmonary exercise testing on a cycle ergometer under direct doctor supervision.

Diagnostic Inclusions:

All Inclusions from The Apollo Functional
Direct VO2 Max Cardiopulmonary Gas Exchange Testing on a precision cycle ergometer
Ventilatory Threshold 1 (Aerobic fat-oxidation ceiling)
Ventilatory Threshold 2 (Anaerobic lactate accumulation point)
Personalized 5-Zone Heart Rate Training Matrix

Candidate Profile & Protocol:

Best For: Athletes, runners, cyclists, and executives who demand empirical physiological training zones instead of smartwatch guesses.
Preparation: Comfortable athletic attire; avoid caffeine for 4 hours prior.

Flagship Longevity Tier

The Orion — The Complete

360° Synthesis: Epigenetics, Microbiome, VO2 Max & Resting Metabolic Rate (RMR)

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Hisential’s definitive longevity assessment. The Orion synthesizes cellular ageing rates, microbial ecology, physical muscle quality, and peak cardiopulmonary endurance with clinical indirect calorimetry to measure your exact basal caloric burn and substrate fuel utilization at rest.

Diagnostic Inclusions:

All Inclusions from The Helios Performance
Resting Metabolic Rate (RMR) via clinical indirect calorimetry canopy
Respiratory Quotient (RQ) substrate breakdown (percentage fats vs carbohydrates burned at rest)
Actual daily basal energy expenditure (kcals/day)
Comprehensive Multi-Omic Physician Action Plan

Candidate Profile & Protocol:

Best For: Patients demanding total precision for metabolic weight management, hormone therapy, and longitudinal healthspan optimization.
Preparation: 4-hour fasting prior to indirect calorimetry session.

Comprehensive Screening Add-Ons

Integrate Organ Biochemistry & Radiological Scans

Pair functional longevity biomarkers with deep blood biochemistry, endocrine panels, and high-resolution ultrasound imaging.

Specialty Hormone & Cardiac Panel

The Bernini

S$999 (Inclusive of GST)

Add to Longevity Tier

Features 82 biomarkers specifically calibrated for deep endocrine, metabolic, and advanced cardiovascular risk stratification.

Hormonal Matrix:

Total & Free Testosterone, SHBG, LH, FSH, Prolactin, Estradiol (E2), and DHEAs.

Metabolic Depth:

Fasting Insulin, HOMA-IR insulin resistance calculation, HbA1c, and Vitamin D3 (25-OH).

Advanced Lipid Subfractions:

Apolipoprotein A1, Apolipoprotein B (ApoB), Apo A1/B ratio, Lipoprotein(a), Homocysteine, and hsCRP.

Organ & Tumour Markers:

Liver FIB-4 index, Vitamin B12, AFP (Liver), CEA (Colon), CA19-9 (Pancreas), and EBV EA IgA.

Flagship Full-Body Health Check

The Da Vinci

S$1,800 (Inclusive of GST)

Add to Longevity Tier

Hisential's flagship traditional health check. Includes 69 biomarkers, Choice of 3 Ultrasound Scans, Bone Mineral Density (BMD), chest X-ray, resting 12-lead ECG, and comprehensive regional cancer markers.

Choice of 3 Ultrasounds:

Prostate, Scrotum, Hepatobiliary, KUB (Kidney, Ureter, Bladder), Thyroid, Pelvis, or Breast.

Radiological & Cardiac:

Bone Mineral Density (BMD), Chest X-Ray, Resting 12-Lead ECG, and Spirometry lung function.

Regional Cancer Markers:

Full panel including EBV VCA IgA (vital nasopharyngeal cancer marker for South-East Asian populations), AFP, CEA, PSA/CA125.

Targeted Interventions

Specialized Optimisation Bundles

Reviewed and validated by Medical Director Dr. Julian Ng.

Athletic Physiology

Performance Max Bundle

Targeted cardiorespiratory and muscular power testing for active individuals.

InBody Segmental Body Composition
Handgrip Dynamometer Strength Test
VO2 Max Cycle Ergometer Gas Analysis
Resting Metabolic Rate (RMR) Calorimetry
Spirometry Lung Function (FEV1, FVC, PEF)

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Metabolic Precision

Weight Management Bundle

Doctor-led metabolic profiling to eliminate caloric and hormonal guesswork.

Physician Weight Management Consultation
Clinical Nutrition Assessment Questionnaire
Individualized Written Exercise Prescription
Resting Metabolic Rate (RMR) direct measurement
InBody Segmental Composition & Visceral Fat

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Nocturnal Restoration

Sleep & Stress Bundle

Objective nocturnal airflow diagnostics and systemic trace element analysis.

Home Sleep Apnoea Test (HSAT in your own bed)
Oxygen Desaturation Index & Pulse Rate Mapping
Zinc, Magnesium, and Serum Ferritin Panel
Total Iron Binding Capacity (TIBC) & Serum Iron
Physician Sleep Hygiene Consultation

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